Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 5, 2026

Slice It Hot: Acute Adult Brain Slicing in Physiological Temperature
08:46

Slice It Hot: Acute Adult Brain Slicing in Physiological Temperature

Published on: October 30, 2014

Recording in the cerebellar slice.

Geoffrey T Swanson1, Anis Contractor

  • 1University of Texas Medical Branch, Galveston, Texas, USA.

Current Protocols in Neuroscience
|April 23, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Translatome profiling reveals opposing alterations in inhibitory and excitatory neurons of fragile X mice and identifies EPAC2 as a therapeutic target.

Neuron·2026
Same author

Subregional activity in the dentate gyrus is amplified during elevated cognitive demands.

eLife·2026
Same author

Exaggerated NMDA Receptor-Primed Metaplasticity via SK Channel Dysregulation in <i>Fmr1</i> Knockout Mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Quantification of Lentiviral Vectors with Nucleic Acid Dyes.

Human gene therapy·2026
Same author

Levetiracetam prevents Aβ production through SV2a-dependent modulation of APP processing in Alzheimer's disease models.

Science translational medicine·2026
Same author

A pathogenic AMPA receptor gating mutation disrupts synapse-mitochondrion axis and stalls synapse maturation.

bioRxiv : the preprint server for biology·2026
Same journal

Simultaneous Ca<sup>2+</sup> Imaging and Optogenetic Stimulation of Cortical Astrocytes in Adult Murine Brain Slices.

Current protocols in neuroscience·2020
Same journal

Automated Two-Chamber Operon ID/ED Task for Mice.

Current protocols in neuroscience·2020
Same journal

A Guide to Fluorescence Lifetime Microscopy and Förster's Resonance Energy Transfer in Neuroscience.

Current protocols in neuroscience·2020
Same journal

Development, Screening, and Validation of Camelid-Derived Nanobodies for Neuroscience Research.

Current protocols in neuroscience·2020
Same journal

Recombinant Antibodies in Basic Neuroscience Research.

Current protocols in neuroscience·2020
Same journal

Automated Quantification of Mitochondrial Fragmentation in an In Vitro Parkinson's Disease Model.

Current protocols in neuroscience·2020
See all related articles

This study details methods for preparing mouse cerebellar slices for electrophysiological recording. These slices serve as a model for motor learning and synaptic transmission research.

Area of Science:

  • Neuroscience
  • Cellular and Molecular Neuroscience

Background:

  • The cerebellum is crucial for motor learning and coordination.
  • Understanding synaptic function in the cerebellum is key to understanding motor control.
  • Cerebellar slices offer a simplified model for studying neural circuits.

Purpose of the Study:

  • To describe the preparation of mouse cerebellar slices.
  • To outline electrophysiological recording techniques for cerebellar neurons.
  • To highlight the utility of cerebellar slices in neuroscience research.

Main Methods:

  • Preparation of acute mouse cerebellar slices.
  • Electrophysiological recordings from cerebellar neurons within slices.
  • Utilizing the defined architecture of cerebellar slices for experiments.

More Related Videos

Assessment of Long-term Depression Induction in Adult Cerebellar Slices
09:30

Assessment of Long-term Depression Induction in Adult Cerebellar Slices

Published on: October 16, 2019

Whole Cell Recording from an Organotypic Slice Preparation of Neocortex
10:29

Whole Cell Recording from an Organotypic Slice Preparation of Neocortex

Published on: June 3, 2011

Related Experiment Videos

Last Updated: Jul 5, 2026

Slice It Hot: Acute Adult Brain Slicing in Physiological Temperature
08:46

Slice It Hot: Acute Adult Brain Slicing in Physiological Temperature

Published on: October 30, 2014

Assessment of Long-term Depression Induction in Adult Cerebellar Slices
09:30

Assessment of Long-term Depression Induction in Adult Cerebellar Slices

Published on: October 16, 2019

Whole Cell Recording from an Organotypic Slice Preparation of Neocortex
10:29

Whole Cell Recording from an Organotypic Slice Preparation of Neocortex

Published on: June 3, 2011

Main Results:

  • Established protocols for obtaining viable mouse cerebellar slices.
  • Demonstrated feasibility of recording neuronal activity in these slices.
  • Highlighted the suitability of this preparation for studying synaptic plasticity.

Conclusions:

  • Mouse cerebellar slices are a valuable preparation for studying motor learning.
  • This model system facilitates the investigation of synaptic transmission principles.
  • The described techniques enable detailed analysis of cerebellar neuronal function.