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Intermittent Binge-Intake Model in Mice

Intermittent Binge-Intake Model in Mice

Published on: January 10, 2025

Sugar bingeing in rats.

Nicole M Avena¹, Pedro Rada, Bartley G Hoebel

¹Princeton University, Princeton, New Jersey, USA.

Current Protocols in Neuroscience

|April 23, 2008

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This summary is machine-generated.

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This study presents a rat model for sugar bingeing, demonstrating behavioral and neurochemical signs of sugar dependence. The findings reveal key indicators of bingeing, withdrawal, and dopamine release in the brain.

Area of Science:

Neuroscience
Behavioral Science
Addiction Research

Background:

Bingeing behavior is a core feature of various eating disorders.
Understanding the neurobiological underpinnings of bingeing is crucial for developing effective treatments.

Purpose of the Study:

To describe and validate an animal model of sugar bingeing in rats.
To investigate the behavioral and neurochemical correlates of sugar dependence using this model.

Main Methods:

Establishment of a sugar bingeing paradigm in a rodent model.
Assessment of behavioral indices including bingeing, withdrawal symptoms, and deprivation effects.
Neurochemical analysis focusing on dopamine release in the nucleus accumbens.
Evaluation of cross-sensitization with psychostimulant drugs like amphetamine.

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A General Method for Evaluating Incubation of Sucrose Craving in Rats

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Sucrose Preference and Novelty-Induced Hypophagia Tests in Rats using an Automated Food Intake Monitoring System

Sucrose Preference and Novelty-Induced Hypophagia Tests in Rats using an Automated Food Intake Monitoring System

Published on: May 8, 2020

Related Experiment Videos

Last Updated: Jul 5, 2026

Intermittent Binge-Intake Model in Mice

Intermittent Binge-Intake Model in Mice

Published on: January 10, 2025

A General Method for Evaluating Incubation of Sucrose Craving in Rats

A General Method for Evaluating Incubation of Sucrose Craving in Rats

Published on: November 4, 2011

Sucrose Preference and Novelty-Induced Hypophagia Tests in Rats using an Automated Food Intake Monitoring System

Sucrose Preference and Novelty-Induced Hypophagia Tests in Rats using an Automated Food Intake Monitoring System

Published on: May 8, 2020

Main Results:

The animal model successfully elicited behavioral signs of sugar dependence.
Repeated sugar bingeing led to significant increases in dopamine release in the nucleus accumbens.
The model demonstrated withdrawal effects and a deprivation effect (increased intake after abstinence).
Cross-sensitization with amphetamine was observed, suggesting shared neurobiological pathways.

Conclusions:

The developed animal model is effective for studying sugar dependence and bingeing behavior.
Sugar bingeing induces neurochemical changes in the brain's reward pathways, particularly dopamine signaling.
This model provides a valuable tool for preclinical research into eating disorders and substance use disorders.