Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spatiotemporal White Matter Pathology in Chronic Cerebral Hypoperfusion: Insights from the BCAS Mouse Model of Vascular Cognitive Impairment and Dementia.

Aging and disease·2026
Same author

Multimodal Single-Cell Transcriptomic and Chromatin Accessibility Profiling Reveals Monocyte-Derived Macrophage Dynamics Following Ischemic Stroke.

International journal of molecular sciences·2026
Same author

Chronic lymphocytic leukemia with <i>IGH</i>::<i>BCL3</i>-translocation is characterized by a homogeneous and distinct genetic and epigenetic landscape.

HemaSphere·2026
Same author

Disruption of the l-DOPA Receptor Gpr143/OA1-Gene in Mice Creates a Unique Mixed Psychosis-Like Phenotype.

Neuropsychopharmacology reports·2026
Same author

Speed meets precision: rapid intraoperative diagnostics in neuro-oncologic surgery.

Trends in cancer·2026
Same author

Adult leptomeningeal vestigial neural crest-derived multipotent cells promote vascular repair after stroke.

Cell reports·2025

Related Experiment Video

Updated: Jul 5, 2026

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain
06:12

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain

Published on: January 27, 2022

Neural stem cell transplantation in mouse brain.

Jean-Pyo Lee1, Scott McKercher, Franz-Josef Muller

  • 1Stem Cell and Regeneration Program, Center for Neuroscience and Aging Research, Burnham Institute for Medical Research, La Jolla, California, USA.

Current Protocols in Neuroscience
|April 23, 2008
PubMed
Summary

Neural stem cell (NSC) transplantation offers regenerative therapy for central nervous system (CNS) diseases. This study details methods for NSC preparation, transplantation into various mouse models, and in situ cell detection for research.

More Related Videos

Surgical Transplantation of Mouse Neural Stem Cells into the Spinal Cords of Mice Infected with Neurotropic Mouse Hepatitis Virus
08:33

Surgical Transplantation of Mouse Neural Stem Cells into the Spinal Cords of Mice Infected with Neurotropic Mouse Hepatitis Virus

Published on: July 10, 2011

Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells
09:29

Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells

Published on: July 10, 2019

Related Experiment Videos

Last Updated: Jul 5, 2026

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain
06:12

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain

Published on: January 27, 2022

Surgical Transplantation of Mouse Neural Stem Cells into the Spinal Cords of Mice Infected with Neurotropic Mouse Hepatitis Virus
08:33

Surgical Transplantation of Mouse Neural Stem Cells into the Spinal Cords of Mice Infected with Neurotropic Mouse Hepatitis Virus

Published on: July 10, 2011

Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells
09:29

Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells

Published on: July 10, 2019

Area of Science:

  • Neuroscience
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Neural stem cells (NSCs) are foundational cells in the nervous system with multipotent differentiation potential.
  • Transplantation of NSCs is a promising therapeutic strategy for central nervous system (CNS) diseases.

Purpose of the Study:

  • To describe established protocols for neural stem cell transplantation in mouse models.
  • To provide methods for the preparation and detection of transplanted neural stem cells.

Main Methods:

  • Protocols for preparing neural stem cells (NSCs) for transplantation.
  • Methods for transplanting NSCs into neonatal, embryonic, and adult mouse brains.
  • Techniques for detecting labeled donor cells in the engrafted mouse brain, including in situ detection of lacZ-expressing cells.

Main Results:

  • Detailed methodologies for neural stem cell preparation and transplantation are presented.
  • Effective methods for detecting transplanted cells in vivo are described.
  • The protocols are applicable across different developmental stages and ages of mouse models.

Conclusions:

  • Established protocols facilitate neural stem cell transplantation research in the central nervous system.
  • These methods support the investigation of NSC-based regenerative therapies for CNS disorders.
  • Accurate detection methods are crucial for evaluating the efficacy of neural stem cell transplantation.