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Using the Reactome database.

Lincoln D Stein1

  • 1Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.

Current Protocols in Bioinformatics
|April 23, 2008
PubMed
Summary
This summary is machine-generated.

Reactome is a comprehensive pathway database detailing human biological pathways and their interactions. It aids researchers in exploring molecular reactions and connections across species using tools like Pathfinder.

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Area of Science:

  • Bioinformatics
  • Systems Biology
  • Molecular Biology

Background:

  • Pathway databases are crucial for bioinformatics research.
  • The Reactome project is a collaborative effort between Cold Spring Harbor Laboratory and the European Bioinformatics Institute.
  • Existing databases require efficient tools for pathway exploration and analysis.

Purpose of the Study:

  • To describe the utilization of the Reactome database for understanding biological pathways.
  • To demonstrate how to identify molecular pathway interactions and connections.
  • To introduce the Pathfinder tool for comprehensive pathway searching.

Main Methods:

  • Utilizing the Reactome database for pathway navigation and browsing.
  • Identifying molecules involved in specific biological pathways.

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  • Employing the Pathfinder tool to search for pathway connections.

    • Main Results:

    • Reactome provides structured information on human biological pathways.
    • Orthologous reactions in model organisms are included.
    • The database facilitates learning pathway steps and inter-pathway interactions.

    Conclusions:

    • Reactome serves as a valuable resource for exploring biological pathways.
    • The database and its tools enable efficient pathway analysis and discovery.
    • Researchers can leverage Reactome to understand molecular mechanisms and their connections.