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Related Concept Videos

Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...

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Related Experiment Video

Updated: Jul 5, 2026

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
09:06

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

Published on: October 24, 2018

Exploring phenotypic data at the rat genome database.

Simon N Twigger1, Jennifer S Smith, Angela Zuniga-Meyer

  • 1Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Current Protocols in Bioinformatics
|April 23, 2008
PubMed
Summary
This summary is machine-generated.

The Rat Genome Database (RGD) offers curated data on rat genes, traits, and genomes. It facilitates research integration across rat, human, and mouse models for biomedical studies.

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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

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Related Experiment Videos

Last Updated: Jul 5, 2026

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
09:06

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

Published on: October 24, 2018

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
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In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Area of Science:

  • Genomics
  • Bioinformatics
  • Comparative Biology

Background:

  • The laboratory rat (Rattus norvegicus) is a crucial model organism in biomedical research.
  • Experimental findings in rats have direct implications for human health and disease studies.
  • Access to curated, integrated data is essential for leveraging rat models effectively.

Purpose of the Study:

  • To provide an overview of the Rat Genome Database (RGD).
  • To demonstrate practical applications of RGD for exploring functional rat data.
  • To illustrate how RGD facilitates cross-species comparative analysis.

Main Methods:

  • Utilizing the Rat Genome Database (RGD) for data retrieval and analysis.
  • Employing RGD's tools for genome association studies.
  • Leveraging comparative mapping and genome analysis features within RGD.

Main Results:

  • RGD provides access to a wide array of curated rat data, including genes, quantitative trait loci, and phenotypes.
  • The database enables users to explore functional genomics and make genome associations.
  • Comparative tools within RGD allow for integration of data across rat, human, and mouse.

Conclusions:

  • RGD is a valuable resource for researchers studying the rat genome and its relevance to human biology.
  • The database enhances the utility of rat models by enabling integrated, cross-species research.
  • Effective use of RGD can accelerate discoveries in human health and disease.