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Decellularized Apple-Derived Scaffolds for Bone Tissue Engineering In Vitro and In Vivo
Published on: February 23, 2024
Hierarchically mesoporous-macroporous bioactive glasses scaffolds for bone tissue regeneration
Hui-suk Yun1, Seung-eon Kim, Yong-taek Hyun
1Center for Future Technology, Korea Institute of Materials Science, Changwon, Gyeongnam, South Korea 641-83. yuni@kims.re.kr
Summary
Hierarchically structured bioactive glasses offer improved molding and bone-forming capabilities. These materials demonstrate excellent biocompatibility with human osteoblastlike cells, paving the way for advanced bone regeneration therapies.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Tissue Engineering
Background:
- Bioactive glasses (BGs) are crucial for bone regeneration.
- Developing BGs with enhanced structural properties and bioactivity remains a challenge.
- Hierarchical porosity can improve cell infiltration and material integration.
Purpose of the Study:
- To synthesize hierarchically 2D/3D mesoporous-macroporous bioactive glasses (MMBG).
- To evaluate the molding capabilities, mechanical properties, and in vitro bioactivity of MMBG.
- To assess the biocompatibility of MMBG with human osteoblastlike cells.
Main Methods:
- Sol-gel method combined with evaporation-induced self-assembly.
- Use of nonionic triblock copolymers (P127, F127) and methyl cellulose as templates.
- In vitro bioactivity testing in simulated body fluid (SBF).
- MTT assay to evaluate cell viability and proliferation (MG63 cells).
Main Results:
- Successful synthesis of hierarchically 2D/3D MMBG with good molding capabilities and compressive modulus.
- MMBG exhibited superior bone-forming bioactivities in vitro.
- MTT assay confirmed excellent biocompatibility of MMBG with human osteoblastlike cells (MG63).
Conclusions:
- Hierarchical mesoporous-macroporous bioactive glasses are promising materials for bone tissue engineering.
- The developed MMBG possess favorable mechanical and biological properties.
- These findings support the potential of MMBG for enhanced bone regeneration applications.
