Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Temporal Aquaporin Expression Profiles in Immune Cell Subsets during Critical Illness.

Shock (Augusta, Ga.)·2026
Same author

The Complement System in the Setting of Critical Illness-A Narrative Review.

Biomolecules·2026
Same author

Effect of testosterone replacement therapy on fracture risk in hypogonadal men: A systematic review and meta-analysis of randomized controlled trials.

Maturitas·2026
Same author

Renal Resistive Index on Admission Predicts and Mediates Acute Kidney Injury: A Prospective Observational Study from a Greek Intensive Care Unit.

Journal of clinical medicine·2026
Same author

Approach to the patient: management of bone fragility in patients with chronic hypoparathyroidism.

The Journal of clinical endocrinology and metabolism·2026
Same author

Machine learning for early detection and prediction of sepsis: explainability and key sepsis biomarkers representation-A systematic review.

International journal of medical informatics·2026

Related Experiment Video

Updated: Jul 5, 2026

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
10:52

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

Systemic sclerosis associated with generalized vasculitis and hypopituitarism.

John C Katsantonis1, John Protopsaltis, Stelios Kokkoris

  • 1Department of Dermatology, 'Tzanio' General Hospital, Tzani 1, 185 36 Piraeus, Greece.

Rheumatology International
|April 26, 2008
PubMed
Summary

Systemic sclerosis (SSc) can cause severe skin ulcers and hypopituitarism due to associated vasculitis. This case highlights rare, potentially linked SSc manifestations not previously reported.

More Related Videos

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Induction of Experimental Autoimmune Hypophysitis in SJL Mice
10:38

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Published on: December 17, 2010

Related Experiment Videos

Last Updated: Jul 5, 2026

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
10:52

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Induction of Experimental Autoimmune Hypophysitis in SJL Mice
10:38

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Published on: December 17, 2010

Area of Science:

  • Rheumatology
  • Endocrinology
  • Dermatology

Background:

  • Systemic sclerosis (SSc) is a complex autoimmune disease affecting multiple organs.
  • Organ involvement in SSc is heterogeneous and can be severe.
  • The etiology of SSc remains largely unknown.

Observation:

  • A 53-year-old female presented with numerous bleeding deep skin ulcers and near collapse.
  • Clinical, autoantibody, histopathology, and immunofluorescence findings were consistent with SSc and vasculitis.
  • Endocrine evaluation revealed severe pituitary gland dysfunction.

Findings:

  • The patient's severe skin ulcerations and hypopituitarism were attributed to SSc-associated vasculitis.
  • This presentation represents a unique combination of SSc manifestations.
  • The findings suggest a potential link between vasculitis, skin integrity, and pituitary function in SSc.

Implications:

  • This case expands the known clinical spectrum of Systemic Sclerosis.
  • It underscores the importance of investigating endocrine complications in SSc patients with severe manifestations.
  • Further research is warranted to understand the mechanisms linking SSc vasculitis to pituitary damage and severe cutaneous disease.