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Raynaud's disease, also known as Raynaud's phenomenon, is a...
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Related Experiment Video

Updated: Jul 5, 2026

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans
08:21

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans

Published on: July 21, 2023

[Primary and secondary Raynaud's phenomenon].

J H W Distler1

  • 1Medizinische Klinik 3 und Institut für klinische Immunologie, Universität Erlangen-Nürnberg, Universitätsstrasse 29, 91054 Erlangen. joerg.distler@uk-erlangen.de

Zeitschrift Fur Rheumatologie
|April 26, 2008
PubMed
Summary

Raynaud's phenomenon is a vasospastic disorder affecting 3-5% of people, causing digital color changes and numbness. Treatments include supportive care and medications like calcium channel blockers.

Area of Science:

  • Vascular Medicine
  • Clinical Physiology

Context:

  • Raynaud's phenomenon is a common condition characterized by abnormal vasospasm.
  • It affects 3-5% of the population, presenting with digital color changes and paresthesia.
  • The condition is classified into primary (idiopathic) and secondary forms.

Purpose:

  • To review the clinical presentation, pathogenesis, and therapeutic strategies for Raynaud's phenomenon.
  • To provide an overview of current treatment options for this vasospastic disorder.

Summary:

  • Raynaud's phenomenon involves exaggerated vasospasm in response to cold or stress, leading to distinct skin color changes and sensory disturbances.
  • Pathogenesis involves vascular smooth muscle cells, endothelial cells, and microvasculature.
  • Therapies encompass supportive measures, topical treatments, and systemic medications, including calcium channel blockers, prostacyclin analogues, fluoxetine, losartan, and sildenafil.

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Last Updated: Jul 5, 2026

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Impact:

  • Enhances understanding of Raynaud's phenomenon for clinicians and researchers.
  • Informs therapeutic decisions by summarizing effective drug classes.
  • Highlights the need for further research into the incompletely understood pathogenesis.