Related Experiment Video
Updated: Jul 5, 2026
06:11
Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection
Published on: May 17, 2024
Blood glucose determinations in large for gestational age infants
Robert S Van Howe1, Michelle R Storms
1Department of Pediatrics and Human Development, Michigan State University College of Human Medicine, Marquette, Michigan 49855, USA.
American Journal of Perinatology
|April 26, 2008
Summary
Higher birthweight does not increase hypoglycemia risk in large for gestational age (LGA) infants. Routine blood glucose screening in healthy LGA infants is not supported by this study, requiring further prospective research.
Area of Science:
- Neonatal Medicine
- Pediatric Endocrinology
Background:
- Large for gestational age (LGA) infants are often monitored for hypoglycemia.
- Factors contributing to hypoglycemia in LGA infants require further investigation.
Purpose of the Study:
- To identify factors associated with hypoglycemia in LGA infants.
- To determine the clinical utility of blood glucose screening in specific infant subsets.
Main Methods:
- Retrospective chart review of LGA infants (36-42 weeks gestation) excluding infants of diabetic mothers.
- Analysis of maternal, intrauterine, and birthweight factors using statistical models.
- Assessment of blood glucose levels within the first 90 minutes of life.
Main Results:
- Lowest blood glucose levels observed in the first 90 minutes of life.
- Gestational age and breastfeeding positively correlated with blood glucose levels.
- Birthweight did not predict hypoglycemia; symptoms occurred only in boys and were linked to lower gestational age.
Conclusions:
- Higher birthweight is not a predictor of hypoglycemia in healthy LGA infants.
- Routine blood glucose monitoring in healthy LGA infants lacks demonstrated clinical value.
- Prospective studies are needed to establish the clinical usefulness of blood glucose screening.
Related Concept Videos
01:22Diabetes Mellitus: Type 2 and Gestational
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
01:25Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
01:29Hyperglycemia
Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
01:20Pathophysiology of Diabetes
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
01:15Hypoglycemia and Glucagon
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
01:15Diabetes: Symptoms, Diagnosis, and Complications
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...