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Androgens and prevention of prostate cancer

Jamey A Sarvis1, Ian M Thompson

  • 1University of Texas Health Science Center, San Antonio, Texas 78229-3900, USA.

Current Opinion in Endocrinology, Diabetes, and Obesity
|April 29, 2008
PubMed
Abstract

Insights

Finasteride is the only proven agent for prostate cancer risk reduction. Ongoing trials explore vitamin E, selenium, and dutasteride, alongside a deeper understanding of androgen pathways for new prevention strategies.

Area of Science:

  • Oncology
  • Endocrinology
  • Urology

Background:

  • Prostate cancer development is intricately linked to the androgen signaling pathway.
  • Understanding these molecular mechanisms is crucial for effective prevention strategies.

Purpose of the Study:

  • To review recent advancements in understanding the role of androgens in prostate cancer prevention.
  • To summarize novel and established therapeutic targets within the androgen pathway.

Main Methods:

  • Comprehensive literature review of recent studies on androgen signaling in prostate cancer.
  • Analysis of molecular mechanisms, therapeutic agents, and clinical trial data.

Main Results:

  • Numerous molecular mechanisms in prostate cancer initiation and progression involve the androgen pathway.
  • While many agents target this pathway, few have reached clinical trials.
  • Finasteride is the sole agent currently proven to reduce prostate cancer risk.

Conclusions:

  • Ongoing phase III trials are investigating vitamin E, selenium, and dutasteride for prostate cancer prevention.
  • Advances in understanding androgen pathway interactions are paving the way for novel risk mitigation approaches.

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