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Updated: Jul 5, 2026

A Method for Mouse Pancreatic Islet Isolation and Intracellular cAMP Determination
Published on: June 25, 2014
[C-peptide residual secretion makes difference on type 1 diabetes management?]
Melanie Rodacki1, Adolpho Milech, José Egídio Paulo de Oliveira
1Serviço de Nutrologia e Diabetes, Universidade Federal do Rio de Janeiro RJ, Brasil. mrodacki@hucff.ufrj.br
Abstract:
Type 1 diabetes is a chronic disease characterized by progressive destruction of the pancreatic beta cells, what leads to insulin deficiency and hyperglycemia. However, a significant secretory function may persist for long periods in a few patients, what is clinically evident through the detection of serum C peptide. This phenomenon might reduce the risk of chronic complications, severe hypoglycemias and allow easier metabolic control. It is possible that these advantages are caused, at least partially, by C peptide itself, acting directly in its target tissues.
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