Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 5, 2026

In vivo Evaluation of Mucociliary Clearance in Mice
06:35

In vivo Evaluation of Mucociliary Clearance in Mice

Published on: December 18, 2020

Modelling mucociliary clearance.

D J Smith1, E A Gaffney, J R Blake

  • 1School of Mathematics, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. D.J.Smith.2@bham.ac.uk

Respiratory Physiology & Neurobiology
|April 29, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of linear polyethyleneimine/nitric oxide adduct on wound repair: therapy versus toxicity.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society·1999
Same author

In vitro reactivation of latent equid herpesvirus-1 from CD5+/CD8+ leukocytes indirectly by IL-2 or chorionic gonadotrophin.

The Journal of general virology·1999
Same author

It's the economy, stupid.

Annals of plastic surgery·1998
Same author

Aerosolized soluble nitric oxide donor improves oxygenation and pulmonary hypertension in acute lung injury.

American journal of respiratory and critical care medicine·1998
Same author

Association of salivary immunoglobulin A antibody and initial mutans streptococcal infection.

Oral microbiology and immunology·1998
Same author

Horticultural therapy: the garden benefits everyone.

Journal of psychosocial nursing and mental health services·1998
Same journal

Weighted Gene Co-expression Network Analysis of Early-Life PM₂.₅-Exposed Lung Transcriptome Identifies Key Gene Modules and Hub Genes Associated with Developmental Programming of COPD Vulnerability.

Respiratory physiology & neurobiology·2026
Same journal

Physiological responses during a maximal dry static breath-hold in a world champion freediver.

Respiratory physiology & neurobiology·2026
Same journal

Intermittent Hypoxemia in Preterm Infants: Glial Fibrillary Acidic Protein as a Potential Brain Injury Biomarker.

Respiratory physiology & neurobiology·2026
Same journal

Asymmetry of thoracic expansion in hemiplegic stroke and its relationship with physical function and percent vital capacity: A cross-sectional study.

Respiratory physiology & neurobiology·2026
Same journal

Evaluating the shape of the expiratory flow volume curve in asymptomatic ex-smokers.

Respiratory physiology & neurobiology·2026
Same journal

Emphysema and airway disease synergistically impair exercise tolerance in smokers: A CT-based study.

Respiratory physiology & neurobiology·2026
See all related articles

Mathematical models of mucociliary clearance (MCC) are reviewed. New insights into ciliary propulsion and fluid dynamics, particularly the interaction between cilia and mucus, are discussed, offering a path for future research.

Area of Science:

  • Fluid mechanics
  • Biophysics
  • Respiratory physiology

Background:

  • Mucociliary clearance (MCC) is vital for airway health, involving coordinated ciliary action on airway surface liquid (ASL).
  • The ASL comprises a mucous layer and a periciliary layer (PCL), with distinct fluid dynamics properties.
  • Previous models of MCC fluid mechanics have yielded conflicting predictions regarding fluid transport within the ASL layers.

Purpose of the Study:

  • To review the evolution of mathematical modeling in MCC fluid mechanics.
  • To discuss discrepancies between theoretical predictions and experimental findings on ASL fluid transport.
  • To highlight recent advances and future challenges in modeling MCC.

Main Methods:

  • Review of theoretical modeling approaches for MCC, including phenomenological, slender body theory, and fluid-structure interaction (FSI) models.

More Related Videos

Collection, Expansion, and Differentiation of Primary Human Nasal Epithelial Cell Models for Quantification of Cilia Beat Frequency
11:13

Collection, Expansion, and Differentiation of Primary Human Nasal Epithelial Cell Models for Quantification of Cilia Beat Frequency

Published on: November 10, 2021

Ex vivo Method for High Resolution Imaging of Cilia Motility in Rodent Airway Epithelia
08:25

Ex vivo Method for High Resolution Imaging of Cilia Motility in Rodent Airway Epithelia

Published on: August 8, 2013

Related Experiment Videos

Last Updated: Jul 5, 2026

In vivo Evaluation of Mucociliary Clearance in Mice
06:35

In vivo Evaluation of Mucociliary Clearance in Mice

Published on: December 18, 2020

Collection, Expansion, and Differentiation of Primary Human Nasal Epithelial Cell Models for Quantification of Cilia Beat Frequency
11:13

Collection, Expansion, and Differentiation of Primary Human Nasal Epithelial Cell Models for Quantification of Cilia Beat Frequency

Published on: November 10, 2021

Ex vivo Method for High Resolution Imaging of Cilia Motility in Rodent Airway Epithelia
08:25

Ex vivo Method for High Resolution Imaging of Cilia Motility in Rodent Airway Epithelia

Published on: August 8, 2013

  • Analysis of experimental data, such as fluorescent tracer transport, to validate and refine MCC models.
  • Investigation of ciliary-mucus interactions and pressure gradients at the PCL/mucus interface.

    • Main Results:

    • Recent FSI models offer new perspectives on how cilia interact with mucus, generating propulsion.
    • Discrepancies in predicted vs. observed fluid transport in PCL and mucus layers are being resolved.
    • Modeling findings correlate with clinical observations, such as enhanced MCC in pseudohypoaldosteronism.

    Conclusions:

    • Advanced FSI modeling provides deeper understanding of MCC mechanisms.
    • Further research is needed to refine models and address limitations in simulating this complex biological system.
    • Improved mathematical models of MCC hold potential for understanding and treating airway diseases.