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Post-methionine load test: A more sensitive tool to reveal hyperhomocysteinemia in Alzheimer patients?
Gloria Galimberti1, Elisa Conti, Michela Zini
1Department of Neuroscience and Biomedical Technology, University of Milano-Bicocca, via Cadore 48, 20052 Monza (MI), Italy. gloria.galimberti@unimib.it
Objective:
To identify the real number of hyperhomocysteinemic Alzheimer's patients who may benefit from homocysteine-lowering therapy.
Methods:
Basal and post-methionine load homocysteine levels were assessed by rp-HPLC system.
Results:
PML test revealed twice as many hyperhomocysteinemic AD subjects with respect to the fasting analysis.
Conclusion:
PML test resulted useful in detecting higher number of hyperhomocysteinemic AD patients who may have the chance of an early folate treatment.
