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Cytokine profile of Armenian patients with Familial Mediterranean fever
G P Manukyan1, K A Ghazaryan, Zh A Ktsoyan
1Group of Molecular and Cellular Immunology and Laboratory of Molecular Genetics, Institute of Molecular Biology, National Academy of Sciences, Yerevan, Armenia.
Objectives:
Despite the well-defined genetics of FMF, limited information is available regarding the regulation of inflammation by cytokines.
Design And Methods:
The levels of systemic cytokines and other markers of inflammation in FMF patients and control were measured by ELISA and Cytometric Bead Array (CBA).
Results:
In FMF attack the levels of IL-6, IL-10, IL-17, TGF-beta, CRP, and sIL-2R were significantly different from the norm and FMF remission.
Conclusions:
Inflammation in FMF involves Treg and Th17 lineages.
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