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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

gpDB: a database of GPCRs, G-proteins, effectors and their interactions

Margarita C Theodoropoulou1, Pantelis G Bagos, Ioannis C Spyropoulos

  • 1Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Athens 157 01, Greece.

Bioinformatics (Oxford, England)
|April 29, 2008
PubMed
Abstract

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G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical, 7TM, or...