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Updated: Jul 5, 2026
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Lethality Bioassay Using Artemia salina L.
Published on: October 11, 2022
[Study on molluscicidal effect of chlorosalicylicamide]
1Department of Chemistry and Chemical Industry, Huazhong University of Science and Technology, Wuhan 430030, China.
Summary
Chlorosalicylicamide effectively kills Oncomelania snails at low concentrations. This new molluscicide demonstrates significantly lower toxicity to fish compared to niclosamide, offering a safer alternative for snail control.
Area of Science:
- Parasitology
- Environmental Toxicology
- Aquatic Ecology
Context:
- Schistosomiasis control relies on managing snail intermediate hosts.
- Oncomelania hupensis snails transmit schistosomiasis.
- Effective and safe molluscicides are crucial for disease prevention.
Purpose:
- To evaluate the molluscicidal efficacy of chlorosalicylicamide against Oncomelania hupensis.
- To assess the toxicity of chlorosalicylicamide to fish species.
- To compare chlorosalicylicamide with niclosamide ethanolamine salt, a standard molluscicide.
Summary:
- Chlorosalicylicamide exhibited high molluscicidal activity against Oncomelania hupensis, achieving 100% mortality at 0.4 mg/L within 48 hours.
- The LC50 for chlorosalicylicamide against snails was 0.0674 mg/L, significantly lower than that of niclosamide (0.3976 mg/L).
- At 0.4 mg/L for 72 hours, chlorosalicylicamide caused 50% fish mortality, whereas niclosamide caused 100% mortality, indicating lower fish toxicity.
Impact:
- Chlorosalicylicamide presents a promising alternative molluscicide with enhanced efficacy and reduced environmental risk.
- This finding supports the development of safer strategies for schistosomiasis vector control.
- Further research can explore large-scale application and long-term ecological effects.
