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Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Hypodermis01:02

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Accessory Structures of the Skin: Hair and Hair Follicles01:16

Accessory Structures of the Skin: Hair and Hair Follicles

Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. It is found on the surface of the skin throughout the body, except for areas such as the palms of the hands and soles of the feet.
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
Histology of the Small Intestine01:27

Histology of the Small Intestine

The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...

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Autoimmune bullous dermatosis in children: French guidelines.

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Bronchial involvement in mucous membrane pemphigoid: 2 cases and a literature review.

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Related Experiment Video

Updated: Jul 5, 2026

Flat Mount Imaging of Mouse Skin and Its Application to the Analysis of Hair Follicle Patterning and Sensory Axon Morphology
13:58

Flat Mount Imaging of Mouse Skin and Its Application to the Analysis of Hair Follicle Patterning and Sensory Axon Morphology

Published on: June 25, 2014

[Functional histology of dermis].

C Prost-Squarcioni1, S Fraitag, M Heller

  • 1Laboratoire d'Histologie du Pr Salzmann, UFR Léonard de Vinci, 93000 Bobigny, France. catherine.prost@avc.aphp.fr

Annales De Dermatologie Et De Venereologie
|May 6, 2008
PubMed
Summary

The skin

Area of Science:

  • Dermatology and Connective Tissue Biology

Background:

  • The skin's dermis is a complex matrix of fibrous and amorphous connective tissues.
  • It contains elastic fibers for skin elasticity and collagen fibers for tensile strength.
  • Key cellular components include fibroblasts, macrophages, and mast cells.

Purpose of the Study:

  • To detail the structural components and cellular players within the skin's dermal layer.
  • To elucidate the molecular composition and functional roles of elastic and collagenous tissues.
  • To describe the functions of resident dermal cells in tissue maintenance and repair.

Main Methods:

  • Histological and ultrastructural examination of dermal connective tissues.
  • Molecular identification of key proteins within elastic and collagen fibers.
  • Functional analysis of dermal resident cells (fibroblasts, macrophages, mast cells).

More Related Videos

Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting
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Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting

Published on: May 7, 2019

Horizontal Whole Mount: A Novel Processing and Imaging Protocol for Thick, Three-dimensional Tissue Cross-sections of Skin
08:31

Horizontal Whole Mount: A Novel Processing and Imaging Protocol for Thick, Three-dimensional Tissue Cross-sections of Skin

Published on: August 2, 2017

Related Experiment Videos

Last Updated: Jul 5, 2026

Flat Mount Imaging of Mouse Skin and Its Application to the Analysis of Hair Follicle Patterning and Sensory Axon Morphology
13:58

Flat Mount Imaging of Mouse Skin and Its Application to the Analysis of Hair Follicle Patterning and Sensory Axon Morphology

Published on: June 25, 2014

Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting
09:14

Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting

Published on: May 7, 2019

Horizontal Whole Mount: A Novel Processing and Imaging Protocol for Thick, Three-dimensional Tissue Cross-sections of Skin
08:31

Horizontal Whole Mount: A Novel Processing and Imaging Protocol for Thick, Three-dimensional Tissue Cross-sections of Skin

Published on: August 2, 2017

Main Results:

  • Elastic fibers comprise mature elastic, elaunin, and oxytalan fibers, with specific molecular constituents like elastin and fibrillins.
  • Collagen fibers, composed of types I, III, and V, provide tensile strength and are associated with FACITs.
  • Dermal cells like fibroblasts, macrophages, and mast cells perform critical roles in matrix synthesis, immune response, and wound healing.

Conclusions:

  • The dermis is a dynamic, integrated system crucial for skin integrity, elasticity, and tensile strength.
  • Specific molecular components and resident cells orchestrate skin structure, function, and response to injury.
  • Understanding these dermal components is vital for research into skin health and disease.