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Updated: Jul 5, 2026
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Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
Published on: November 10, 2023
Sleep-disordered breathing before and after lung transplantation
Monique A Malouf1, Maree A Milrose, Maree A Milross
1Lung Transplant Unit, St. Vincent's Hospital, Darlinghurst, Australia. mmalouf@stvincents.com.au
Summary
Sleep-disordered breathing (SDB) is prevalent in lung transplant candidates. While lung transplantation can improve oxygenation, new cases of SDB may emerge post-surgery.
Area of Science:
- Pulmonology
- Sleep Medicine
- Transplant Surgery
Background:
- Sleep-disordered breathing (SDB) is common in severe chronic respiratory failure.
- Prevalence and post-transplant effects of SDB in lung transplant candidates are unknown.
Purpose of the Study:
- Determine SDB prevalence before lung transplantation.
- Evaluate the impact of lung transplantation on SDB.
Main Methods:
- Polysomnography (PSG) performed on 117 lung transplant candidates.
- SDB defined by respiratory disturbance index (RDI) or nocturnal oxygen desaturation.
- Repeat PSG post-transplant in 25 subjects.
Main Results:
- 40% of patients on room air (n=80) had SDB.
- SDB resolved in 6/11 patients post-transplant.
- 4/14 patients developed new-onset SDB post-transplant.
- Pre-transplant SDB did not affect survival to or after transplant.
Conclusions:
- Sleep-disordered breathing is common in lung transplant candidates.
- Lung transplantation can improve oxygenation but may lead to new SDB onset.
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