Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single stage revision ankle arthroplasty, Is it safe?

Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons·2025
Same author

Hydrogeochemical assessment and water quality of glacier-fed catchment of Chenab basin, Kishtwar Himalaya, Jammu and Kashmir, India.

Environmental science and pollution research international·2025
Same author

The sobering effects of binge drinking.

Journal of osteopathic medicine·2024
Same author

Quantitative analysis of soil quality around brick kilns using pollution indices and ANOVA in Jammu district of Jammu and Kashmir, India.

Environmental research·2024
Same author

Phytobial remediation advances and application of omics and artificial intelligence: a review.

Environmental science and pollution research international·2024
Same author

Pollution indices and correlation of heavy metals contamination in the groundwater around brick kilns in Jammu and Kashmir, India.

Heliyon·2024

Related Experiment Video

Updated: Jul 5, 2026

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease
08:57

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease

Published on: May 22, 2026

Current concepts in diastolic heart failure.

Sunil Dhar1, Deepak Koul, Gilbert E D'Alonzo

  • 1Temple University Hospital-Episcopal Campus, 100 E Lehigh Ave, Philadelphia, PA 19125-1012, USA. darsk@tuhs.temple.edu

The Journal of the American Osteopathic Association
|April 30, 2008
PubMed
Summary

Diastolic heart failure, characterized by preserved ejection fraction but abnormal diastolic function, is common in older adults and women. Early diagnosis and management with medications like calcium channel blockers can improve outcomes compared to systolic heart failure.

More Related Videos

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

Related Experiment Videos

Last Updated: Jul 5, 2026

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease
08:57

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease

Published on: May 22, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

Area of Science:

  • Cardiology
  • Internal Medicine

Background:

  • Heart failure is a widespread condition, especially affecting elderly individuals and women.
  • Diastolic heart failure, also known as heart failure with normal ejection fraction, preserves left ventricular systolic function but shows abnormal diastolic function.
  • Clinical and radiographic presentation of diastolic heart failure often mimics systolic heart failure.

Purpose of the Study:

  • To review current medical concepts of diastolic heart failure for primary care physicians.
  • To highlight the importance of early diagnosis and management in improving patient prognosis.

Main Methods:

  • Review of current medical literature and treatment guidelines for diastolic heart failure.
  • Focus on diagnostic methods, particularly echocardiography, to differentiate from systolic heart failure.
  • Discussion of therapeutic strategies, emphasizing calcium channel blockers and angiotensin receptor blockers.

Main Results:

  • Echocardiography is crucial for identifying preserved ejection fraction with abnormal diastolic function.
  • Calcium channel blockers and angiotensin receptor blockers are key treatment options.
  • Early diagnosis and appropriate management are associated with a more favorable prognosis than systolic heart failure.

Conclusions:

  • Diastolic heart failure requires specific diagnostic approaches due to its similarity to systolic heart failure.
  • Effective management strategies, including pharmacotherapy, can significantly alter the disease trajectory.
  • Primary care physicians are pivotal in the early detection and ongoing care of patients with diastolic heart failure.