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Viral protein cleavages as a drug design target
1Central Research and Development Department, Du Pont Company Experimental Station E 328, Wilmington, Delaware 19880-0328.
Acta Biologica Hungarica
|January 1, 1991
Abstract:
Many animal and plant viruses encode proteolytic enzymes which are involved in regulation of viral replication and assembly. The proteases are becoming well-characterized, and offer attractive features for the design of selective antiviral agents. Approaches to the assay of viral protease inhibitors and the various classes identified are described.