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A cellular anti-apoptosis protein is cleaved by the HIV-1 protease
B D Korant1, P Strack, M W Frey
1DuPont Merck Pharmaceutical Co., Experimental Station, Wilmington, Delaware 19880-0336, USA.
Advances in Experimental Medicine and Biology
|April 30, 1998
Abstract:
Cleavage of non-viral proteins is rarely observed with the HIV-1 protease (HIV pr). One such cleavage event occurs with bcl-2, an important cytoprotective protein. The loss of bcl-2 has biological consequences, leading to enhanced HIV replication and programmed death of the host cell. A strategy is proposed to suppress HIV with non-cleavable mutants of bcl-2.