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Updated: Jul 5, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
11:44

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

Rationally designed nanostructures for surface-enhanced Raman spectroscopy.

Matthew J Banholzer1, Jill E Millstone, Lidong Qin

  • 1Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113, USA.

Chemical Society Reviews
|April 30, 2008
PubMed
Summary
This summary is machine-generated.

Surface-enhanced Raman spectroscopy (SERS) enables molecular detection. Nanotechnology advancements are improving SERS substrate design for higher sensitivity and reproducibility in chemical and biological sensing.

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Area of Science:

  • Nanotechnology
  • Spectroscopy

Background:

  • Surface-enhanced Raman spectroscopy (SERS) offers molecular probing capabilities.
  • Current SERS applications include chemical/biological detection and authentication.
  • Fabrication challenges limit SERS substrate sensitivity, tunability, robustness, and reproducibility.

Purpose of the Study:

  • To review recent advancements in SERS substrate design and fabrication.
  • To highlight the impact of nanotechnology on overcoming SERS limitations.

Main Methods:

  • Focus on nanotechnology-driven approaches for SERS substrate development.
  • Emphasis on controlling nanoscale features for enhanced Raman signals.

Main Results:

  • Nanotechnology enables the creation of SERS substrates with improved sensitivity.
  • New fabrication methods enhance substrate stability and reproducibility.
  • Control over nanoscale features is key to SERS enhancement.

Conclusions:

  • Nanotechnology is crucial for advancing SERS substrate performance.
  • Overcoming fabrication limitations is essential for practical SERS applications.
  • Future SERS systems will benefit from nanostructured substrates.