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Updated: Jul 5, 2026

A Filter-based Surface Enhanced Raman Spectroscopic Assay for Rapid Detection of Chemical Contaminants

A Filter-based Surface Enhanced Raman Spectroscopic Assay for Rapid Detection of Chemical Contaminants

Published on: February 19, 2016

Quantitative surface-enhanced Raman spectroscopy.

Steven E J Bell¹, Narayana M S Sirimuthu

¹Innovative Molecular Materials Group, School of Chemistry and Chemical Engineering, Queen's University, Belfast, UK BT9 5AG. s.bell@qub.ac.uk

Chemical Society Reviews

|April 30, 2008

Summary

This summary is machine-generated.

Surface-enhanced Raman (SERS) and resonance Raman (SERRS) spectroscopy are now quantitative analytical techniques. This review discusses controlling factors for stable, reproducible SERS/SERRS calibrations, enabling high-sensitivity applications.

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Area of Science:

Analytical Chemistry
Spectroscopy
Materials Science

Background:

Conventional Raman spectroscopy offers molecular fingerprinting but lacks sensitivity.
Surface-enhanced Raman (SERS) and resonance Raman (SERRS) spectroscopy significantly amplify Raman signals.
These techniques hold promise for sensitive and selective molecular detection.

Purpose of the Study:

To demonstrate the evolution of SERS and SERRS into quantitative analytical methods.
To highlight the potential of SERS/SERRS for applications requiring high sensitivity and molecular discrimination.
To discuss the critical factors for establishing reliable SERS/SERRS calibrations.

Main Methods:

Review of advancements in SERS and SERRS techniques.
Analysis of factors influencing signal stability and reproducibility.
Discussion of calibration strategies for quantitative analysis.

Main Results:

SERS and SERRS have matured into viable quantitative analytical techniques.
High sensitivity and excellent molecular discrimination are achievable.
Low-cost, compact spectrometers are compatible with SERS/SERRS.

Conclusions:

SERS and SERRS offer significant advantages over conventional Raman spectroscopy.
Controlling specific parameters is essential for reproducible quantitative SERS/SERRS measurements.
These techniques are poised for widespread application in various analytical fields.