Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Altered neurovascular coupling during information-processing states.

Myles Jones1, Ian M Devonshire, Jason Berwick

  • 1The Centre for Signal Processing in Neuroimaging and Systems Neuroscience, Department of Psychology, University of Sheffield, Western Bank, Sheffield S10 2TP, UK. m.jones@sheffield.ac.uk

The European Journal of Neuroscience
|May 1, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peer Employment Learning Center (PELC) Pilot Project: From Mental Patient to Peer Support Provider.

Community mental health journal·2026
Same author

Contralateral delay activity as a marker of visual working memory capacity: A multi-site registered replication.

Cortex; a journal devoted to the study of the nervous system and behavior·2026
Same author

The superior colliculus gates dopamine responses to conditioned stimuli in visual classical conditioning.

Nature communications·2026
Same author

Goals of care discussions in hospitalised patients: systematic review of randomised trials.

BMJ supportive & palliative care·2025
Same author

Disassociating cerebral vasomotion from low frequency spontaneous neurovascular coupling.

Scientific reports·2025
Same author

Assessment of shared decision-making tool for eliciting informed goals of care in the hospitalized elderly (ASKmeGOC): protocol for a randomized clinical trial.

Trials·2025
Same journal

Improved Motor Neuron Preservation and Axonal Recovery Following Experimental Sciatic Nerve Repair With Heterologous Fibrin Biopolymer.

The European journal of neuroscience·2026
Same journal

Topography of Regional Cerebral GABA<sub>A</sub> Receptor Availability in Parkinson's Disease Patients With Freezing of Gait.

The European journal of neuroscience·2026
Same journal

Enhanced Time-Locked Decoding for Spoken Words but Not Environmental Sounds in Natural-Like Auditory Conditions.

The European journal of neuroscience·2026
Same journal

Learning Dynamics in Biophysical Spiking Network Models Are Shaped by KCC2/NKCC1 Cotransporter Stoichiometry.

The European journal of neuroscience·2026
Same journal

Dopamine Receptor Agonism in the Nucleus Accumbens Shell During Aversive Learning or Memory Retrieval: Differential Effects Depending on the Degree of Sugar Familiarity.

The European journal of neuroscience·2026
Same journal

Training in the Categorization of Aerial and Terrestrial Scenes Differentially Impacts Scene-Selective and Nonscene-Selective Regions in Occipitotemporal Cortex.

The European journal of neuroscience·2026
See all related articles

Neurovascular coupling, the link between brain activity and blood flow, changes with brain states. This study shows altered hemodynamic responses during arousal, impacting how neural activity is detected.

Area of Science:

  • Neuroscience
  • Physiology
  • Biomedical Engineering

Background:

  • Brain imaging relies on neurovascular coupling, linking neural activity to hemodynamic changes.
  • The constancy of neurovascular coupling across different brain states is not well understood.

Purpose of the Study:

  • To investigate how neurovascular coupling varies during different baseline cortical activity states.
  • To examine the relationship between neural activity and hemodynamic responses during quiescence versus arousal.

Main Methods:

  • Used optical imaging spectroscopy, laser Doppler flowmetry, and electrophysiology in anesthetized rats.
  • Measured hemodynamic and neural activity in the barrel cortex.
  • Compared responses to whisker stimulation during baseline quiescence and brainstem-stimulated cortical desynchronization (arousal).

Related Experiment Videos

Main Results:

  • Cortical desynchronization increased baseline blood flow, volume, and oxygenation.
  • Hemodynamic responses to low-frequency stimuli were attenuated during arousal, while neural responses were less affected.
  • High-frequency stimuli enhanced neural activity during arousal but yielded similar hemodynamic responses as during quiescence.

Conclusions:

  • Neurovascular coupling is state-dependent, varying with baseline cortical activity.
  • Differences in stimulus-evoked neural activity and hemodynamics exist between quiescence and arousal states.
  • This suggests potential alterations in information processing during different brain states.