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Updated: Jul 5, 2026
12:21
Fabrication and Characterization of Griffithsin-modified Fiber Scaffolds for Prevention of Sexually Transmitted Infections
Published on: October 31, 2017
Development of controlled release sildenafil formulations for vaginal administration
I Tuncer Değim1, Fatmanur Tuğcu-Demiröz, Sibel Tamer-Ilbasmis
1Faculty of Pharmacy, Department of Pharmaceutical Technology, Gazi University, Ankara, Turkey. tunc@tr.net
Drug Delivery
|May 1, 2008
Summary
Sildenafil, approved for male sexual dysfunction, shows promise for female infertility treatment. Researchers developed novel suppositories and vaginal inserts for effective sildenafil delivery.
Area of Science:
- Reproductive Medicine
- Pharmaceutics
- Drug Delivery Systems
Background:
- Sildenafil is FDA-approved for male sexual dysfunction.
- Emerging research suggests potential applications for female infertility.
- Currently, no pharmaceutical preparations exist for this indication.
Purpose of the Study:
- To develop and evaluate novel sildenafil formulations for potential female infertility treatment.
- To investigate suitable drug release profiles for vaginal administration.
Main Methods:
- Preparation of sildenafil-containing suppositories utilizing Eudragit RS100 and Witepsol H15.
- Development of a vaginal insert incorporating EVAC 210 polymer and sildenafil.
- Evaluation of sildenafil release characteristics from the prepared formulations.
Main Results:
- Sildenafil-containing suppositories demonstrated suitable sildenafil release.
- The vaginal insert formulation provided sustained sildenafil release over an extended period.
Conclusions:
- Novel suppository and vaginal insert formulations show potential for sildenafil delivery in women.
- These formulations may offer a viable therapeutic option for female infertility, warranting further investigation.
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