Related Experiment Video
Updated: Jul 5, 2026

Operation of the Collaborative Composite Manufacturing (CCM) System
Published on: October 1, 2019
An RCM strategy to stereodiverse delta-sultam scaffolds
María Jiménez-Hopkins1, Paul R Hanson
1Department of Chemistry, University of Kansas, Lawrence, Kansas 66045-7582, USA.
Abstract:
An asymmetric approach for the synthesis of substituted delta-sultams with multiple synthetic handles is described. This study demonstrates the facile construction of a stereochemically diverse array of substituted delta-sultams, more specifically substituted 3,4,5,6-dihydro 1,2-thiazine 1,1-dioxides. A pivotal Mitsunobu alkylation/RCM sequence is used to assemble key allyl sultam building blocks possessing a C3 stereogenic handle. All subsequent reactions are achieved with high levels of diastereoselectivity to afford enantiopure delta-sultams in good yields.
More Related Videos
12:54Density Gradient Multilayered Polymerization (DGMP): A Novel Technique for Creating Multi-compartment, Customizable Scaffolds for Tissue Engineering
Published on: February 12, 2013
08:23Fabricating Complex Culture Substrates Using Robotic Microcontact Printing (R-µCP) and Sequential Nucleophilic Substitution
Published on: October 31, 2014
Related Concept Videos
Diels–Alder Reaction Forming Cyclic Products: Stereochemistry
Naming Enantiomers
Stereoisomerism of Cyclic Compounds
Radical Halogenation: Stereochemistry
Halogenation to form a new chiral center:
Stereoisomerism
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Molecules with Multiple Chiral Centers