Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tissue Renewal without Stem Cells

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

Liver Regeneration

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Source And Potency Of Stem Cells

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...

Multipotency of Hematopoietic Stem Cells

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Synergistic anti-hypernociceptive interaction between morphine and JM-20 in neuropathic rats. Mechanistic insights into metabolism, transport, and safety.

Chemico-biological interactions·2025

Same author

Sinusoidal Obstruction Syndrome After Allogeneic Hematopoietic Cell Transplantation With Post-Transplant Cyclophosphamide.

Transplantation and cellular therapy·2025

Same author

Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen.

Antioxidants (Basel, Switzerland)·2022

Same author

Factors that influence the quality of metabolomics data in in vitro cell toxicity studies: a systematic survey.

Scientific reports·2021

Same author

Extracting consistent biological information from functional results of metabolomic pathway analysis using the Mantel's test.

Analytica chimica acta·2021

Same author

Toward Rapid Screening of Liver Grafts at the Operating Room Using Mid-infrared Spectroscopy.

Analytical chemistry·2020

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

Manual Isolation of Adipose-derived Stem Cells from Human Lipoaspirates

Manual Isolation of Adipose-derived Stem Cells from Human Lipoaspirates

Published on: September 26, 2013

[Adipose tissue-derived stem cells: hepatic plasticity].

Ana Bonora-Centelles¹, José Vicente Castell, María José Gómez-Lechón

¹Unidad de Hepatología Experimental, Centro de Investigación, Hospital Universitario La Fe, Valencia, España.

Gastroenterologia Y Hepatologia

|May 2, 2008

Summary

Adult stem cells from adipose tissue show promise for liver regeneration and therapy. This research reviews their differentiation into liver cells for treating liver failure and metabolic disorders.

More Related Videos

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate

Published on: October 31, 2012

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

Published on: May 19, 2018

Related Experiment Videos

Last Updated: Jul 5, 2026

Manual Isolation of Adipose-derived Stem Cells from Human Lipoaspirates

Manual Isolation of Adipose-derived Stem Cells from Human Lipoaspirates

Published on: September 26, 2013

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate

Published on: October 31, 2012

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

Published on: May 19, 2018

Area of Science:

Hepatology
Stem Cell Biology
Regenerative Medicine

Background:

Liver transplantation is the only effective treatment for end-stage liver disease.
A significant imbalance exists between donor liver availability and patient demand.
Stem cell therapy offers a promising alternative for liver disease treatment.

Purpose of the Study:

To review advancements in differentiating adult stem cells from adipose tissue into cells with a hepatic phenotype.
To discuss the therapeutic potential of adipose-derived stem cells for liver disease.

Main Methods:

Review of current literature on adipose-derived stem cell differentiation.
Analysis of studies demonstrating hepatic differentiation of adult stem cells.
Discussion of potential clinical applications.

Main Results:

Adult stem cells from adipose tissue exhibit plasticity and can be differentiated into various cell types.
Hepatic differentiation of these stem cells has shown promising results.
Adipose tissue is an abundant and accessible source for stem cell isolation.

Conclusions:

Adipose-derived stem cells are a viable source for hepatic stem cell therapy.
This therapy holds potential for metabolic support in liver failure patients awaiting transplantation.
It may also aid in liver regeneration and treating genetic metabolic liver defects.