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Related Experiment Video

Updated: Jul 5, 2026

Generation of Human Induced Pluripotent Stem Cell-derived Planar Hair-bearing Skin Organoids Using an Air-Liquid Interface Culture System

Generation of Human Induced Pluripotent Stem Cell-derived Planar Hair-bearing Skin Organoids Using an Air-Liquid Interface Culture System

Published on: October 17, 2025

Volatile organic compounds produced by human skin cells.

Cristian A Acevedo¹, Elizabeth Y Sánchez, Juan G Reyes

¹Biotechnology Center, Universidad Técnica Federico Santa María, Valparaíso, Chile.

Biological Research

|May 2, 2008

Summary

Skin cells release volatile organic compounds (VOCs) that change based on culture conditions. This suggests VOC profiles can indicate the physiological state of skin cells and skin.

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Generation and Culturing of Primary Human Keratinocytes from Adult Skin

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Published on: December 22, 2017

Area of Science:

Biochemistry
Dermatology
Metabolomics

Background:

Skin continuously releases volatile organic compounds (VOCs) into the environment.
These VOCs exhibit emission patterns influenced by climatic conditions.
Metabolic pathways contain volatile intermediates, suggesting a link between cell metabolism and VOC production.

Purpose of the Study:

To investigate if culture conditions affect the volatile organic compound (VOC) profiles of human dermal fibroblasts.
To determine if VOC profiles can serve as indicators of skin cell physiological status.

Main Methods:

Primary cultures of human dermal fibroblasts were utilized.
Gas chromatography was employed to analyze VOCs.
Cells were cultured under different conditions, including 2D monolayer and 3D matrix immobilization.

Main Results:

Significant differences in VOC profiles were observed between 2D and 3D cultures.
The type of culture condition demonstrably altered the VOC output of skin cells.

Conclusions:

The study demonstrates that VOC profiles are sensitive to the culture environment of skin cells.
VOC analysis holds potential for assessing the physiological state of skin cells and skin in general.