Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
Polymers: Molecular Weight Distribution01:10

Polymers: Molecular Weight Distribution

For any given polymer, the weight average molecular weight (Mw) is higher than, if not equal to, the number average molecular weight (Mn). The only situation in which the weight average molecular weight and the number average molecular weight are equal is when a polymer consists only of chains with equal molecular weight. However, this never happens in a synthetic polymer, since it is difficult to control the polymerization process up to a molecular level with accuracy to a hundred percent.
Immunoprecipitation01:20

Immunoprecipitation

Immunoprecipitation, or IP, is a widely used technique that employs protein-antibody interactions to isolate proteins or protein complexes in their native state for studying protein-protein interactions, quaternary structures, or supramolecular complexes. Various modifications of the technique, including chromatin IP, cross-linking IP, and fluorescence IP, are commonly used.
Chromatin Immunoprecipitation
Chromatin immunoprecipitation, also known as ChIP, is used to study protein-DNA or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Establishing a living systematic review of characterisation and parameter reporting in lithium-ion and lithium-sulfur cathode research.

Discover electrochemistry·2026
Same author

Recommendations for HLA Genotyping Data Standards and Clinical Laboratory Staffing Considerations.

HLA·2026
Same author

Do conditional marketing authorisations actually accelerate patient access? Time-to-access of conditional vs. standard marketing authorisations in Italy, Spain, and Germany.

Journal of pharmaceutical policy and practice·2026
Same author

Phase I multi-center clinical and biomarker study of the dual-action androgen receptor inhibitor ONCT-534.

Investigational new drugs·2026
Same author

Nomenclature for Factors of the HLA System, 2026.

HLA·2026
Same author

Experimental quantification of resistance to subsidence conferred by endplate-specific expandable implants in anterior lumbar interbody fusion.

Journal of orthopaedic surgery and research·2026
Same journal

Tracking Synthetic Adhesins on Bacterial Surfaces with Immunofluorescence Microscopy.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Post-Selection Methods for Analyzing mRNA Display Selections and Optimization of Hits.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

High-Performance Computing in Tandem Mass Spectrometry (MS/MS) Peptide Identification.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Engineering and Adapting Disulfide-Containing Proteins to Enable Intracellular Functionality.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

AI-Driven Protein Research: From Prediction to Design.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Methods for the In Vitro Selection of Protein and Peptide Libraries Using mRNA Display.

Methods in molecular biology (Clifton, N.J.)·2026
See all related articles

Related Experiment Video

Updated: Jul 5, 2026

Predictive Immune Modeling of Solid Tumors
08:50

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

IPD: the Immuno Polymorphism Database.

James Robinson1, Steven G E Marsh

  • 1Anthony Nolan Research Institute, Royal Free Hospital, Hampstead, London, UK.

Methods in Molecular Biology (Clifton, N.J.)
|May 3, 2008
PubMed
Summary
This summary is machine-generated.

The Immuno Polymorphism Database (IPD) centralizes genetic data for immune system research. It offers specialized databases for killer cell immunoglobulin-like receptors (KIRs), major histocompatibility complex (MHC), platelet antigens (HPA), and tumor cell lines (ESTAB).

More Related Videos

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
08:51

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Published on: March 15, 2019

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Related Experiment Videos

Last Updated: Jul 5, 2026

Predictive Immune Modeling of Solid Tumors
08:50

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
08:51

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Published on: March 15, 2019

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Area of Science:

  • Immunogenetics
  • Bioinformatics
  • Molecular Biology

Background:

  • The study of polymorphic genes within the immune system is crucial for understanding immune responses and diseases.
  • Specialized databases are needed to manage and disseminate complex genetic information.
  • Existing resources may lack comprehensive coverage or specific functionalities for immunogenetic research.

Purpose of the Study:

  • To introduce and describe the Immuno Polymorphism Database (IPD) as a centralized resource for immunogenetic data.
  • To outline the structure and content of the four constituent IPD databases: IPD-KIR, IPD-MHC, IPD-HPA, and IPD-ESTAB.
  • To highlight the collaborative model used for data curation and publication within the IPD project.

Main Methods:

  • The IPD project aggregates and curates data from specialist groups and nomenclature committees.
  • Data is stored in a relational database structure, with similar data types sharing common schemas (e.g., IPD-KIR and IPD-MHC).
  • Online publication ensures accessibility and dissemination of curated immunogenetic sequences and information.

Main Results:

  • The IPD provides access to allelic sequences for killer cell immunoglobulin-like receptors (KIRs).
  • It includes a comprehensive database of major histocompatibility complex (MHC) sequences across various species.
  • IPD also offers data on platelet-specific alloantigens (HPA) and a cell bank of immunologically characterized melanoma cell lines (IPD-ESTAB).

Conclusions:

  • The Immuno Polymorphism Database (IPD) serves as a vital, integrated resource for researchers studying immune system genetics.
  • Its structure facilitates the management and accessibility of diverse immunogenetic data, including KIR, MHC, HPA, and tumor cell line information.
  • The collaborative curation model ensures the quality and relevance of the data for the scientific community.