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Updated: Jul 5, 2026

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
Published on: June 6, 2025
Treatment of Philadelphia chromosome-positive adult acute lymphoblastic leukemia
1Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL), Hematology Department, Edouard Herriot Hospital, Lyon, France. xavier.thomas@chu-lyon.fr
Abstract:
The use of imatinib, as part of front-line treatment and in combination with cytotoxic agents, has greatly improved the proportions of complete response and molecular remission, and overall outcome in adults with newly diagnosed Philadelphia chromosome acute lymphoblastic leukemia. New challenges have emerged with respect to induction of resistance to imatinib via ABL mutations. Several novel kinase inhibitors with significantly more potent anti-leukemic activity than imatinib are currently being developed.
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