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Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
Correlation between BMD and bone scintigraphy in patients with prostate cancer
Hakki Perk1, Mustafa Yildiz, Alim Kosar
1Department of Urology, School of Medicine, Suleyman, Demirel University, Isparta, Turkey. feraycinevre@yahoo.com
Urologic Oncology
|May 3, 2008
Summary
Prostate cancer patients with bone metastases show higher bone mineral density (BMD) in the pelvis and trunk compared to healthy individuals. This finding may indicate a prevalence of osteoblastic metastases, aiding in diagnosis and monitoring.
Area of Science:
- Oncology
- Radiology
- Bone Metabolism
Background:
- Bone metastasis is a significant cause of morbidity in prostate cancer patients.
- Accurate detection and monitoring of bone lesions are critical for effective prostate cancer treatment.
Purpose of the Study:
- To evaluate total and regional bone mineral density (BMD) in prostate cancer patients with and without bone metastases.
- To compare BMD measurements with bone scintigraphy findings.
Main Methods:
- Dual-energy X-ray absorptiometry (DXA) and bone scintigraphy were performed on 54 prostate cancer patients and 20 healthy controls.
- Bone scintigraphy findings were categorized into normal (score 0), abnormal but not typical for metastases (score 1), and typical for metastases (score 2).
Main Results:
- Prostate cancer patients with bone metastases exhibited significantly higher total BMD and regional BMD of the trunk and pelvis compared to healthy controls and those without metastases.
- A significant positive correlation was observed between bone scan score and total BMD, as well as regional BMD of the trunk and pelvis.
Conclusions:
- Patients with prostate cancer and bone metastases demonstrate increased BMD in the pelvis and trunk.
- This increase in BMD may be attributed to a predominance of osteoblastic metastases, as suggested by Tc-99m MDP bone scan results.
