Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Physiologic basis for improved pulmonary function after lung volume reduction.

Henry E Fessler1, Steven M Scharf, Edward P Ingenito

  • 1Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. hfessler@jhmi.edu

Proceedings of the American Thoracic Society
|May 6, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Artificial intelligence in sleep medicine I: Diagnosis, treatment, care, and research" [Sleep Med Rev 88 (2026) 102295].

Sleep medicine reviews·2026
Same author

Mortality in narcolepsy and other sleep clinic patients: a 25-year propensity-matched VA cohort study.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2026
Same author

Artificial intelligence in sleep medicine I: Diagnosis, treatment, care, and research.

Sleep medicine reviews·2026
Same author

Hypercapnia-Regulated Molecular Pathways: Mechanistic Insights Into CO₂-Driven Cellular Signaling and Therapeutic Implications.

Cell biochemistry and function·2026
Same author

Mortality in US veterans with insomnia, sleep apnea, and comorbid insomnia and sleep apnea (COMISA); an exploratory, hypothesis-generating cohort study.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2026
Same author

A Synopsis of the 2025 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline for the Primary Care Management of Asthma.

Annals of internal medicine·2026
Same journal

Note from the editor.

Proceedings of the American Thoracic Society·2012
Same journal

Adaptation, evaluation, and updating of guidelines: article 14 in Integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report.

Proceedings of the American Thoracic Society·2012
Same journal

Disseminating and implementing guidelines: article 13 in Integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report.

Proceedings of the American Thoracic Society·2012
Same journal

Reporting and publishing guidelines: article 12 in Integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report.

Proceedings of the American Thoracic Society·2012
Same journal

Moving from evidence to developing recommendations in guidelines: article 11 in Integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report.

Proceedings of the American Thoracic Society·2012
Same journal

How to integrate multiple comorbidities in guideline development: article 10 in Integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report.

Proceedings of the American Thoracic Society·2012
See all related articles

Lung volume reduction surgery (LVRS) improves pulmonary function in emphysema by optimizing lung size and restoring mechanical breathing advantages. Understanding these mechanisms aids in patient selection for better outcomes.

Area of Science:

  • Pulmonology
  • Thoracic Surgery
  • Respiratory Physiology

Background:

  • Emphysema causes elevated residual volume, reducing lung function and worsening breathing mechanics.
  • Lung volume reduction surgery (LVRS) aims to improve pulmonary function in emphysema patients.
  • Current understanding of LVRS mechanisms is crucial for patient selection.

Purpose of the Study:

  • To elucidate the mechanisms by which lung volume reduction surgery improves pulmonary function in emphysema.
  • To identify patient characteristics that predict successful outcomes following LVRS.
  • To compare surgical LVRS with newer bronchoscopic lung volume reduction methods.

Main Methods:

  • Review of physiological principles underlying emphysema and lung mechanics.

Related Experiment Videos

  • Analysis of the effects of LVRS on lung volumes, expiratory flow rates, and inspiratory muscle function.
  • Discussion of patient selection criteria for heterogeneous emphysema.

    • Main Results:

    • LVRS improves lung-to-thorax volume matching, enhancing forced expiratory volumes.
    • Surgery restores mechanical advantage for inspiratory muscles, reducing breathing effort.
    • In heterogeneous emphysema, LVRS can allow healthy lung tissue to expand into resected areas.

    Conclusions:

    • Understanding LVRS mechanisms is key to selecting patients likely to benefit.
    • LVRS offers significant functional improvements by addressing emphysema-related mechanical derangements.
    • Further research into bronchoscopic techniques is needed to overcome challenges in emphysematous lungs.