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Updated: Jul 5, 2026

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mirMachine: A One-Stop Shop for Plant miRNA Annotation
Published on: May 1, 2021
Mireval: a web tool for simple microRNA prediction in genome sequences
William Ritchie1, François-Xavier Théodule, Daniel Gautheret
1INSERM U928, Technologies Avancées pour le Génome et la Clinique, Luminy Case 906, 13288 Marseille, Cedex 09, France. W.Ritchie@centenary.org.au
Bioinformatics (Oxford, England)
|May 6, 2008
Summary
Researchers created mirEval, a user-friendly online tool for discovering novel microRNAs (miRNAs) across various species. This bioinformatics tool simplifies complex in-silico miRNA detection for researchers, enabling efficient sequence analysis.
Area of Science:
- Bioinformatics
- Genomics
- Molecular Biology
Background:
- Identifying novel microRNAs (miRNAs) is crucial for understanding gene regulation.
- Existing in-silico methods for miRNA detection can be complex and require specialized knowledge.
Purpose of the Study:
- To develop a comprehensive and user-friendly online tool for the detection of novel microRNAs.
- To enable researchers without prior in-silico expertise to identify potential miRNAs in large sequences.
Main Methods:
- Development of the mirEval web server.
- Implementation of successful in-silico approaches for microRNA prediction.
- Capability to analyze sequences up to 10,000 nucleotides (nt) in length.
Main Results:
- A novel online tool, mirEval, has been successfully developed.
- The tool facilitates the search for novel microRNAs in multiple organisms.
- mirEval is designed to be comprehensive, easy to use, and informative.
Conclusions:
- mirEval empowers users to investigate sequences for novel microRNAs effectively.
- The tool democratizes in-silico microRNA detection, making advanced methods accessible.
- This resource aids in the discovery of new miRNAs across diverse species.
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
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