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Amplifying Signals via Second Messengers01:15

Amplifying Signals via Second Messengers

Many receptor binding ligands are hydrophilic; they do not cross the cell membrane but bind to cell-surface receptors. Thus, their message must be relayed by second messengers present in the cell cytoplasm. There are several second messenger pathways, each with its own way of relaying information. For example, the G protein-coupled receptors can activate both phosphoinositol and cyclic AMP (cAMP) second messenger pathways. The phosphoinositol pathway is active when the receptor induces...
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When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze the...

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The ripple effect: advancing faculty research?

Carole Kenner1, Jana L Pressler

  • 1College of Nursing, University of Oklahoma, Oklahama City, Oklahoma 73117, USA. Carole-Kenner@ouhsc.edu

Nurse Educator
|May 6, 2008
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Summary
This summary is machine-generated.

New nursing deans often lack preparation for leadership roles. This article offers practical survival tips for academic nursing executives, covering contract negotiation, team building, and organizational agility.

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Area of Science:

  • Nursing Leadership
  • Academic Administration
  • Healthcare Management

Background:

  • Many newly appointed nursing deans and assistant/interim deans possess insufficient formal education, experience, or background for their executive positions.
  • The transition into academic nursing leadership roles presents unique challenges requiring specific skill sets and knowledge.

Purpose of the Study:

  • To provide practical guidance and survival tips for new and aspiring nursing deans.
  • To address common issues, challenges, and opportunities encountered by academic nursing executive teams.

Main Methods:

  • The authors, experienced deans, share personal insights and practical advice based on their leadership experiences.
  • The content focuses on actionable strategies for navigating key administrative functions.

Main Results:

  • Key areas covered include executive contract negotiation, securing faculty lines, and developing effective work teams.
  • Strategies for managing challenging personnel and establishing adaptable organizational structures are discussed.

Conclusions:

  • New nursing deans can benefit from practical, experience-based guidance to effectively manage their roles and institutions.
  • Proactive strategies in contract negotiation, team management, and organizational design are crucial for success in academic nursing leadership.