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Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report
Published on: February 12, 2018
[Central serous chorioretinopathy (CSC) and corticosteroids].
B M Stoffelns1, C Kramann, K Schoepfer
1Augenklinik der Johannes-Gutenberg-Universität, Mainz. stoffelns@augen.klinik.uni-mainz.de
Klinische Monatsblatter Fur Augenheilkunde
|May 6, 2008
Summary
Exogenous corticosteroid use is strongly linked to central serous chorioretinopathy (CSC). Patients using steroids showed higher rates of bilateral disease and multiple leakage points, indicating a significant association.
Area of Science:
- Ophthalmology
- Endocrinology
Background:
- Corticosteroids are suspected to contribute to central serous chorioretinopathy (CSC) development.
- Investigating the role of exogenous steroid exposure in CSC etiology.
Purpose of the Study:
- To evaluate the association between corticosteroid use and the development and course of central serous chorioretinopathy (CSC).
Main Methods:
- Prospective study of 46 consecutive CSC patients (April 2004 - December 2005).
- Detailed analysis of medical/ocular history, focusing on corticosteroid use (oral, IV, inhaled, topical, intraarticular) within 4 weeks of symptom onset.
- Inclusion of cases with Cushing's disease and pregnancy.
Main Results:
- 30/46 patients reported recent corticosteroid use; 21 (70%) had bilateral CSC, 10 (33%) had multiple leakage points.
- 16/46 patients without steroid history showed only 2 (13%) bilateral cases and one (6%) multiple leakage point.
- Recurrences were noted in 21/46 patients, with 8/8 recurrent cases involving patients on systemic corticosteroids.
Conclusions:
- Strong evidence supports a link between steroid use and CSC.
- Systemic corticosteroid treatment increases the likelihood of bilateral involvement and multilocular leakages in CSC.
- Patients requiring corticosteroids should be informed about the potential risk of developing CSC.
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