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Updated: Jul 5, 2026

Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells
Published on: March 31, 2021
Endothelial stem cells and precursors for tissue engineering: cell source, differentiation, selection, and
Saejeong Kim1, Horst von Recum
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Abstract:
Endothelial cells are of great interest because of their potential in cell therapy for vascular diseases and ischemic tissue, tissue engineering for vascular grafts and vascularized tissue beds, and modeling for pharmaceutical transport across endothelial barriers. However, limited availability and proliferation capability of mature endothelial cells hampers development of these applications. Recent advances in stem cell technology have enabled researchers to derive endothelial or endothelial-like cells from stem cells or other precursor populations. The current state of these cell sources and their in vitro differentiation, selection, and applications are discussed in this review.
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