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Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

Source And Potency Of Stem Cells

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

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Related Experiment Video

Updated: Jul 5, 2026

Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells

Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells

Published on: March 31, 2021

Endothelial stem cells and precursors for tissue engineering: cell source, differentiation, selection, and

Saejeong Kim¹, Horst von Recum

¹Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.

Tissue Engineering. Part B, Reviews

|May 6, 2008

Summary

Researchers are exploring stem cells to create endothelial cells for treating vascular diseases and engineering tissues. This review covers current methods for deriving and using these cells.

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Area of Science:

Regenerative Medicine
Cell Biology
Vascular Biology

Background:

Endothelial cells are crucial for vascular health and have therapeutic potential.
Limited supply and poor proliferation of mature endothelial cells hinder applications.
Stem cell technology offers a promising alternative for generating endothelial cells.

Purpose of the Study:

To review current stem cell-derived endothelial cell sources.
To discuss in vitro differentiation and selection strategies.
To explore applications in cell therapy, tissue engineering, and pharmaceutical modeling.

Main Methods:

Review of recent scientific literature on stem cell-derived endothelial cells.
Analysis of differentiation protocols and selection techniques.
Evaluation of current and potential applications.

Main Results:

Stem cell technology enables the generation of endothelial or endothelial-like cells.
Various stem cell populations and differentiation methods are available.
These cells show promise for vascular repair, tissue engineering, and drug transport studies.

Conclusions:

Stem cell-derived endothelial cells represent a viable alternative to mature endothelial cells.
Further research is needed to optimize differentiation, selection, and clinical translation.
These cells hold significant potential for advancing vascular disease treatment and regenerative medicine.