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[Relevance of chemoprevention from PCPT trial]
1Service d'Urologie de l'Hôpital La Milletrie, Université Poitiers, CHU Poitiers, France. j.irani@chu-poitiers.fr
Abstract:
Chemoprevention involves the active use of a drug inhibiting carcinogenesis in order to prevent the development of cancer. Prostate cancer has a high prevalence, long latent period and screening is inadequate. The morbidity and mortality of prostate cancer are significant, making it a good candidate for chemoprevention. Finasteride meets most of the necessary criteria for a chemoprevention agent. Nevertheless, some further information still needs to be obtained before considering its use in practice: the real nature of the increase in Gleason score, envisaged health savings, side effects on sexuality, impact on patient survival and the ideal target population.
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