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Related Experiment Video

Updated: Jul 5, 2026

A Pressure Injection System for Investigating the Neuropharmacology of Information Processing in Awake Behaving Macaque Monkey Cortex
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Scopolamine impairs auditory delayed matching-to-sample performance in monkeys.

Bethany Plakke1, Chi-Wing Ng, Amy Poremba

  • 1University of Iowa, Department of Psychology, Iowa City, IA 52242, USA.

Neuroscience Letters
|May 6, 2008
PubMed
Summary

The cholinergic system is crucial for auditory short-term memory. Blocking muscarinic receptors with scopolamine impaired auditory memory performance in rhesus monkeys in a dose-dependent manner.

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Pharmacology

Background:

  • Information on neurotransmitters critical for auditory memory is limited.
  • The cholinergic system is implicated in visual short-term memory and attention.

Purpose of the Study:

  • To investigate the role of the cholinergic system in auditory short-term memory.
  • To determine the effects of scopolamine on auditory memory performance in rhesus monkeys.

Main Methods:

  • Rhesus monkeys were trained on an auditory go/no-go delayed matching-to-sample (DMTS) task.
  • Scopolamine hydrochloride was administered at varying doses (3, 5, 10 μg/kg) or saline.
  • Performance was assessed on match and nonmatch trials with variable memory delays.

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Last Updated: Jul 5, 2026

A Pressure Injection System for Investigating the Neuropharmacology of Information Processing in Awake Behaving Macaque Monkey Cortex
09:46

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Published on: March 14, 2016

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents
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Published on: July 8, 2015

Testing for Metacognitive Responding Using an Odor-based Delayed Match-to-Sample Test in Rats
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Testing for Metacognitive Responding Using an Odor-based Delayed Match-to-Sample Test in Rats

Published on: June 18, 2018

Main Results:

  • Scopolamine impaired performance accuracy on match trials in a dose-dependent manner.
  • Motor responses, food motivation, and responses to rewarded sounds were not significantly impaired.
  • These findings suggest a specific role for the cholinergic system in auditory memory.

Conclusions:

  • The cholinergic system plays a significant role in auditory short-term memory.
  • Muscarinic receptor blockade by scopolamine selectively impacts auditory memory, not general motivation or motor function.