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Related Experiment Video

Updated: Jul 5, 2026

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
08:51

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Published on: May 10, 2019

Novel approach to select genes from RMA normalized microarray data using functional hearing tests in aging mice.

Mary D'Souza1, Xiaoxia Zhu, Robert D Frisina

  • 1Department of Otolaryngology, University of Rochester School of Medicine & Dentistry, 601 Elmwood Avenue, Rochester, NY 14642-8629, USA.

Journal of Neuroscience Methods
|May 6, 2008
PubMed
Summary
This summary is machine-generated.

Age-related hearing loss involves changes in GABA receptor gene expression in the cochlea. Specific GABA-A receptor subunits and associated proteins show altered expression with aging and hearing impairment in mice.

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Area of Science:

  • Neuroscience
  • Genetics
  • Otolaryngology

Background:

  • Presbycusis, or age-related hearing loss, is a major health concern for the elderly.
  • High-throughput technologies offer potential for identifying diagnostic and therapeutic targets for hearing disorders.

Purpose of the Study:

  • To analyze gene expression of GABA receptors in the cochlea of aging mice.
  • To correlate gene expression changes with functional hearing measures.

Main Methods:

  • Gene expression analysis using Affymetrix GeneChip MOE430A in aging CBA mice.
  • Functional hearing assessments including auditory brainstem response (ABR) and distortion-product otoacoustic emission (DPOAE).
  • Statistical analysis including ANOVA, linear regression, and real-time PCR for validation.

Main Results:

  • GABA-A receptor subunit alpha6 expression was upregulated with age and hearing loss.
  • GABA-A receptor subunit alpha1 was repressed with age and hearing loss.
  • GABA-A receptor associated proteins like-1 and like-2 were downregulated with aging and hearing impairment.

Conclusions:

  • Specific GABA receptor gene expression changes correlate with age-related hearing loss in mice.
  • These findings may identify novel targets for diagnosing and treating presbycusis.