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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...

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Updated: Jul 5, 2026

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
07:17

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

Immunodeficiency-associated lymphomas.

Huy Tran1, Jamie Nourse, Sara Hall

  • 1Department of Haematology, Princess Alexandra Hospital, Ipswich Road, Brisbane, Queensland, 4102, Australia.

Blood Reviews
|May 6, 2008
PubMed
Summary
This summary is machine-generated.

Lymphoproliferative disorders in immunocompromised patients, including those with primary immunodeficiencies or acquired conditions like HIV, present unique challenges. Understanding these lymphomas, often extranodal and virus-associated, offers insights into broader lymphoma pathogenesis.

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Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
07:52

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Published on: January 9, 2019

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Last Updated: Jul 5, 2026

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
07:17

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
07:52

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Published on: January 9, 2019

Area of Science:

  • Immunology
  • Oncology
  • Virology

Background:

  • Primary immunodeficiencies (e.g., Ataxia Telangiectasia, Wiskott-Aldrich syndrome) and acquired immunodeficiencies (e.g., HIV infection, post-transplant immunosuppression) increase lymphoma risk.
  • The global rise in HIV and organ transplantation highlights the growing importance of these lymphomas.
  • Autoimmune treatments (methotrexate, TNF antagonists) are also linked to lymphoma development.

Purpose of the Study:

  • To review lymphoproliferative disorders in immunocompromised individuals.
  • To explore the diverse clinical and etiological factors contributing to these lymphomas.
  • To discuss pathogenic mechanisms with potential implications for immunocompetent individuals.

Main Methods:

  • Literature review of lymphoproliferative disorders in primary and acquired immunodeficiency settings.
  • Analysis of clinical characteristics, including extranodal disease frequency.
  • Examination of viral associations, particularly Epstein-Barr virus (EBV), and alternative pathways.

Main Results:

  • Lymphoproliferations in immunodeficiency are highly heterogeneous, reflecting diverse immune defects.
  • Extranodal disease is a frequent clinical hallmark of these lymphomas.
  • While Epstein-Barr virus (EBV) is often implicated, non-EBV driven lymphomas also occur, indicating multiple pathogenic routes.

Conclusions:

  • Lymphomas in immunocompromised patients are diverse and often extranodal.
  • Viral infections, like EBV, play a significant role, but other mechanisms are also involved.
  • Studying these lymphomas provides a paradigm for understanding altered immune regulation in broader lymphoma contexts.