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Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

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Published on: November 16, 2018

Zinc-containing phosphate-based glasses for tissue engineering.

V Salih1, A Patel, J C Knowles

  • 1Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, 256 Gray's Inn Road, London, WC1X 8LD, UK.

Biomedical Materials (Bristol, England)
|May 7, 2008
PubMed
Summary
This summary is machine-generated.

Adding zinc to phosphate-based glasses enhances osteoblast cell adhesion, crucial for tissue engineering. These zinc-containing glasses show promising results for bone regeneration applications.

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Area of Science:

  • Biomaterials Science
  • Materials Chemistry
  • Tissue Engineering

Background:

  • Zinc incorporation into hydroxyapatite enhances osteoblast cell adhesion.
  • Phosphate-based glasses are investigated for biomedical applications.

Purpose of the Study:

  • To synthesize and characterize phosphate-based glass compositions with varying zinc content.
  • To evaluate the effect of zinc on osteoblast-like cell adhesion and material properties.

Main Methods:

  • Phosphate-based glass discs (P(50)Ca((40-x))Na(10), x = 0-5 mol%) were prepared.
  • Dissolution rates, pH changes, and ion release were measured in distilled water at 37°C.
  • Osteoblast-like cell (HOB) attachment was assessed using Scanning Electron Microscopy (SEM).

Main Results:

  • All glass compositions exhibited similar, linear mass loss (3-6% over 7 days).
  • Dissolution led to a pH decrease to 4.5-5.5, with higher zinc content causing a greater reduction.
  • Zinc ion (Zn(2+)) release was detected from all zinc-containing glasses, and HOB attachment was observed.

Conclusions:

  • Phosphate-based glasses with varying zinc content demonstrate controlled dissolution and ion release.
  • The presence of zinc supports osteoblast-like cell adhesion.
  • These zinc-doped phosphate glasses show potential for tissue engineering applications, particularly in bone regeneration.