[Isolated hepatic perfusion for treatment of unresectable malignant tumor]

Isolated hepatic perfusion (IHP) is the best regional chemotherapy modality for treatment of unresectable liver primary cancer and liver metastases. The main principle of isolated hepatic chemotherapy is to achieve higher regional drug concentrations and thus higher exposure of tumor tissue to the agents, resulting in increased response rates, while shielding the organism from the systemic toxicity because of the much lower concentrations in the systemic circulation. At present the methods of IHP include surgical methods and methods with balloon catheter technique, which promise to provide a micro invasive procedure, but are not fully mature. The key point of successful IHP is low leakage or leakage free. The more beneficial aspect of IHP is that it can simultaneously apply hyperthermy and biologic agent TNF to improve sensitivity of chemotherapy, which is not possible in other regional chemotherapy. From previous literatures this overview is to describe the principle, procedure techniques, leakage monitor methods, hyperthermy application, administration agents, therapeutic reaction, complications and perspective of IHP.