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Updated: Jul 5, 2026
07:58
Cell-Free DNA Integrity Analysis in Urine Samples
Published on: January 5, 2017
Association between polymorphisms in cell cycle genes and advanced prostate carcinoma
Adam S Kibel1, Carol H Jin, Aleksandra Klim
1Department of Surgery, Washington University School of Medicine, Barnes-Jewish Hospital, St. Louis, Missouri 63110, USA. kibela@wustl.edu
The Prostate
|May 7, 2008
Summary
Single nucleotide polymorphisms (SNPs) in cell cycle genes may predict aggressive prostate cancer (PCa). The MDM2 tSNP309g variant showed a significant association with advanced PCa risk in European-Americans.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Single nucleotide polymorphisms (SNPs) are linked to various cancers, including prostate carcinoma (PCa).
- Identifying SNPs associated with aggressive PCa is crucial, given that many patients have low-risk disease.
- This study investigates SNPs in cell cycle genes for their association with advanced PCa.
Purpose of the Study:
- To explore the role of specific single nucleotide polymorphisms (SNPs) in cell cycle genes.
- To determine if these SNPs are associated with advanced prostate carcinoma (PCa).
Main Methods:
- Evaluated nine SNPs in six cell cycle genes within a European-American cohort.
- Included 186 patients with advanced PCa and 222 cancer-free controls.
- Genotypes determined using Pyrosequencing assays.
Main Results:
- One SNP (CDKN1A c10791t) showed statistical significance (P<0.05).
- Two SNPs (CCND1 a870g and MDM2 tSNP309g) approached significance (P<0.1).
- The MDM2 tSNP309g variant was associated with increased risk of advanced PCa (OR 2.26), particularly in androgen-independent disease and younger diagnoses.
Conclusions:
- SNPs in cell cycle genes show promise as markers for aggressive PCa in European-Americans.
- Further research with larger cohorts is necessary to validate these findings.
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