Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

Adult Stem Cells

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...

Renewal of Skin Epidermal Stem Cells

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...

Multipotency and Niche of Bulge Stem Cell

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Biologically engineered vectors enable topical mRNA delivery for skin regeneration.

Communications biology·2026

Same author

The biology of human hair: A multidisciplinary review.

American journal of human biology : the official journal of the Human Biology Council·2019

Same author

Age-related evolutions of the dermis: Clinical signs, fibroblast and extracellular matrix dynamics.

Mechanisms of ageing and development·2018

Same author

The hair follicle enigma.

Experimental dermatology·2017

Same author

The skin aging exposome.

Journal of dermatological science·2016

Same author

Glycobiology to the rescue !

Experimental dermatology·2016

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin

Published on: March 31, 2011

[Human skin stem cells].

Bruno A Bernard¹

¹L'OREAL Recherche, Centre C. Zviak, 90 rue du Général Roguet, 92110 Clichy, France. bbernard@rd.loreal.com

Journal De La Societe De Biologie

|May 8, 2008

Summary

This summary is machine-generated.

Human adult stem cells maintain skin renewal. While epidermal stem cells remain elusive, hair follicle stem cells are localized and characterized, offering potential for regenerative medicine.

More Related Videos

Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells

Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells

Published on: April 18, 2019

Naïve Adult Stem Cells Isolation from Primary Human Fibroblast Cultures

Naïve Adult Stem Cells Isolation from Primary Human Fibroblast Cultures

Published on: May 3, 2013

Related Experiment Videos

Last Updated: Jul 5, 2026

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin

Published on: March 31, 2011

Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells

Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells

Published on: April 18, 2019

Naïve Adult Stem Cells Isolation from Primary Human Fibroblast Cultures

Naïve Adult Stem Cells Isolation from Primary Human Fibroblast Cultures

Published on: May 3, 2013

Area of Science:

Dermatology
Stem Cell Biology
Regenerative Medicine

Background:

Human epidermis renewal relies on adult stem cells in the basal layer.
Epidermal stem cells are enriched and functionally characterized, but their precise location is unknown.
The human hair follicle also regenerates from stem cells.

Purpose of the Study:

To localize, enrich, and characterize human hair follicle stem cells.
To establish the gene expression pattern of hair follicle stem cells.
To investigate the hair follicle as a source of multipotent cells for regeneration.

Main Methods:

Cellular localization and enrichment techniques.
Functional and biochemical characterization of stem cells.
Gene expression profiling.

Main Results:

Human hair follicle stem cells, including melanocyte stem cells, have been successfully localized and characterized.
A specific gene expression pattern for hair follicle stem cells was established.
The hair follicle was identified as a reservoir of multipotent cells.

Conclusions:

Hair follicle stem cells are localized and well-characterized, unlike epidermal stem cells.
The hair follicle serves as a valuable source of stem cells for tissue regeneration.