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Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Related Experiment Video

Updated: Jul 5, 2026

An Array-based Comparative Genomic Hybridization Platform for Efficient Detection of Copy Number Variations in Fast Neutron-induced Medicago truncatula Mutants
09:32

An Array-based Comparative Genomic Hybridization Platform for Efficient Detection of Copy Number Variations in Fast Neutron-induced Medicago truncatula Mutants

Published on: November 8, 2017

Array-based high-throughput DNA markers for crop improvement.

P K Gupta1, S Rustgi, R R Mir

  • 1Molecular Biology Laboratory, Department of Genetics and Plant Breeding, Ch. Charan Singh University, Meerut, Uttar Pradesh, India. pkgupta36@vsnl.com

Heredity
|May 8, 2008
PubMed
Summary
This summary is machine-generated.

Array-based molecular markers, like single nucleotide polymorphisms (SNPs), offer high-throughput genotyping for genetic mapping and diversity analysis in plants and animals. These advanced systems are cost-effective and essential for future genomic research.

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Last Updated: Jul 5, 2026

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Area of Science:

  • Genomics
  • Molecular Biology
  • Plant Science

Background:

  • Molecular marker development has advanced significantly over the last two decades.
  • Early markers like restriction fragment length polymorphisms (RFLPs) have been superseded by high-throughput methods.
  • Single nucleotide polymorphisms (SNPs) are abundant but require prior sequence information.

Purpose of the Study:

  • To describe the characteristics of novel array-based marker systems.
  • To review the development and application of these markers in various organisms.
  • To highlight the future potential of microarray-based markers.

Main Methods:

  • Review of existing literature on molecular marker technologies.
  • Description of array-based assays including SNP platforms, single feature polymorphisms, diversity array technology, and restriction site-associated DNA markers.
  • Analysis of marker utility in high-density mapping, quantitative trait loci (QTL) mapping, and genetic diversity studies.

Main Results:

  • Microarray-based assays enable ultra-high throughput and low-cost genotyping.
  • Novel marker systems provide efficient tools for genetic analysis.
  • These markers are applicable across diverse organisms, from yeast to complex plant genomes.

Conclusions:

  • Array-based molecular markers represent the future of genomic research due to their efficiency and cost-effectiveness.
  • They facilitate advanced applications such as high-density genetic mapping and expression QTL analysis.
  • Continued development and application of these markers will accelerate genetic studies in various species.