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Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
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Published on: August 18, 2020

Hostility among methamphetamine users experiencing psychotic symptoms.

Rebecca McKetin1, Jennifer McLaren, Dan I Lubman

  • 1National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia.

The American Journal on Addictions
|May 9, 2008
PubMed
Summary
This summary is machine-generated.

Hostility is common in methamphetamine users with psychotic symptoms. Severe or prolonged psychosis increases the risk of pathological hostility in these individuals.

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Area of Science:

  • Psychiatry
  • Neuroscience
  • Addiction Medicine

Background:

  • Methamphetamine use is associated with psychosis.
  • Hostility is a significant concern in individuals with substance-induced psychosis.

Purpose of the Study:

  • To quantify the prevalence and severity of hostility in methamphetamine users experiencing psychotic symptoms.
  • To identify factors associated with increased hostility in this population.

Main Methods:

  • A cohort of 71 methamphetamine users with recent psychotic symptoms was assessed.
  • The Brief Psychiatric Rating Scale (BPRS) was used to measure psychotic symptoms and hostility.
  • Hostility was assessed during the most severe psychotic episode in the past year.

Main Results:

  • 27% of participants reported pathological hostility (BPRS score 4+) during their most severe psychotic episode.
  • Hostility was significantly more prevalent in cases of severe psychotic symptoms (42%) or those lasting over two days (43%).
  • Daily heroin use and lower educational attainment correlated with hostility.

Conclusions:

  • Clinically significant hostility frequently co-occurs with psychotic symptoms in methamphetamine users.
  • Severity and duration of psychotic symptoms are key predictors of hostility.
  • These findings highlight the need for integrated treatment approaches for methamphetamine-induced psychosis and associated hostility.