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Updated: Jul 5, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
[Role of immune system in the pathomechanism of obstructive sleep apnea]
Joanna Chorostowska-Wynimko1, Marta E Kedzior
1Samodzielna Pracownia Diagnostyki Molekularnej Instytutu Gruzlicy i Chorob Pluc w Warszawie, Poland.
Abstract:
Immune system plays an essential role in the pathomechanism of obstructive sleep apnea syndrome (OSA), in the development of certain OSA complications, like the increased risk of cardiovascular diseases. Indeed, it is the sleep fragmentation and chronic intermittent hypoxia/reoxygenation, that stimulates increased immunoreactivity and chronic inflammatory response, both systemic and local in the upper airways. This review summarizes current evidence on the most important regulatory mechanisms involving immune cells and mediators.
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