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Published on: May 19, 2023
Periostin and bone marrow fibrosis.
Eijiro Oku1, Taisuke Kanaji2, Yuka Takata1
1Division of Haematology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
International Journal of Hematology
|May 10, 2008
Summary
This study shows periostin is present in bone marrow (BM) fibrosis and secreted by stromal cells, potentially driving disease progression. However, plasma periostin levels did not correlate with fibrosis extent.
Area of Science:
- Biochemistry
- Cell Biology
- Pathology
Background:
- Periostin is a secreted protein found in connective tissues under mechanical stress.
- Previously identified as a component of bronchial asthma fibrosis.
- Its role in bone marrow (BM) fibrosis was investigated.
Purpose of the Study:
- To investigate the relationship between periostin and bone marrow fibrosis.
- To determine if periostin is a component of BM fibrosis and if it influences disease progression.
Main Methods:
- Analysis of periostin expression in BM fibrosis specimens.
- Correlation of periostin levels with fibrosis grade via silver staining.
- Measurement of plasma periostin levels.
- Investigation of periostin secretion by human BM hTERT stromal cells and its regulation by TGF-beta.
Main Results:
- Periostin was expressed in the stroma and stromal cells of BM fibrosis.
- Periostin expression levels closely correlated with the grade of BM fibrosis.
- No relationship was found between plasma periostin levels and the extent of BM fibrosis.
- Periostin is secreted by human BM hTERT stromal cells, with secretion enhanced by TGF-beta.
Conclusions:
- Periostin is a component of bone marrow fibrosis.
- Periostin secreted by stromal cells may play a role in BM fibrosis progression.
- Plasma periostin levels are not indicative of the extent of BM fibrosis.
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