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Updated: Jul 5, 2026
10:56
A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
Published on: September 15, 2018
Treatment of hypercholesterolemia
1Medical Department II, Klinikum Grossharden, Marchioninstr 15, 81377 Munich, Germany. parhofer@med2.med.uni-muenchen.de
Idrugs : the Investigational Drugs Journal
|May 10, 2008
Summary
High LDL-cholesterol is a major risk factor for atherosclerosis. This review covers epidemiological data and treatment strategies for managing LDL-hypercholesterolemia to reduce atherosclerotic disease risk.
Area of Science:
- Cardiovascular Medicine
- Metabolic Disorders
- Epidemiology
Background:
- Hypercholesterolemia is a significant risk factor for atherosclerotic disease.
- Low-density lipoprotein cholesterol (LDL-C) concentration strongly correlates with atherosclerosis incidence.
- High-density lipoprotein cholesterol (HDL-C) concentration is inversely correlated with atherosclerosis.
Purpose of the Study:
- To review the epidemiological evidence linking LDL-hypercholesterolemia to atherosclerosis.
- To discuss current therapeutic options for managing LDL-hypercholesterolemia.
Main Methods:
- Review of epidemiological studies on cholesterol and atherosclerosis.
- Analysis of therapeutic interventions for LDL-hypercholesterolemia.
Main Results:
- Strong positive correlation between LDL-cholesterol and atherosclerosis.
- Inverse correlation between HDL-cholesterol and atherosclerosis.
- Epidemiological data supports LDL-C as a primary target for intervention.
Conclusions:
- LDL-hypercholesterolemia is a key driver of atherosclerotic disease.
- Effective management of LDL-cholesterol is crucial for preventing atherosclerosis.
- Review provides insights into evidence-based treatment strategies.
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